Position Description

Associate Director, Chemistry
Location Agios Pharmaceuticals HQ
Job Code 1019
# of openings 1
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Associate Director, Chemistry

Agios (agios.com) is a biopharmaceutical company committed to applying our scientific leadership in cellular metabolism to transform the lives of patients with cancer and rare genetic diseases. We are growing rapidly with an active research and discovery pipeline across both therapeutic areas. Agios has two approved oncology precision medicines and multiple first-in-class investigational therapies in clinical and/or preclinical development.

POSITION OVERVIEW

Agios is searching for an Associate Director to join our medicinal chemistry department. We are seeking a highly motivated and energetic medicinal chemist with extensive experience working on an integrated/multidisciplinary drug discovery team.  The successful candidate will be responsible for driving medicinal chemistry efforts in a fast-paced small molecule discovery research team through Hit ID, Lead Generation (LG), Lead Optimization (LO), and compound selection as a chemistry/project leader. Applicants should have broad medicinal chemistry experience from hit ID to development compound selection and track record of innovation and creative problem solving. The individual should be an expert in organic chemistry and possess broad scientific knowledge of state-of-the-art principles and theories in medicinal chemistry. The candidate should have deep understanding of molecular properties and DMPK concepts that lead to the discovery of high-quality molecules. The individual will be expected to participate in the writing and execution of patent applications, and interface with or lead internal cross-functional teams and external collaborators as well as CROs.

PRINCIPAL RESPONSIBILITIES

  • Provide innovative and effective leadership in medicinal chemistry from hit ID through clinical candidate selection
  • Co-lead a drug discovery project team with a biology co-leader to drive every aspect of the project including scientific decisions and budgetary proposals
  • Responsible for the success of the chemistry aspects of the drug discovery team through individual contributions and leading an external chemistry team
  • Develop strong design solutions to medicinal and synthetic chemistry challenges
  • Develop and ensure high quality and effective interactions cross functionally to support and achieve project goals and objectives
  • Planning and effectively employing external chemistry resources deliver high quality compounds for biological evaluation

DESIRED SKILLS AND EXPERIENCE

  • Ph.D. in Organic Chemistry, Medicinal Chemistry or related field with 8-12 years industrial experience as a medicinal chemist in a pharmaceutical or biotech company
  • Demonstrated success in leading chemistry and projects teams to deliver high quality compounds into development
  • Expert in medicinal chemistry from hit ID to compound selection with broad and in depth knowledge of drug discovery and related disciplines (i.e. ADME, DMPK, toxicology, etc) with a connection to the laboratory.
  • Proficient and knowledgeable in SAR, FBDD, SBDD and other medicinal chemistry platforms, yet possesses the intuition of a drug hunter
  • Expert in synthetic organic chemistry with creative imagination to design novel chemotypes and solve synthetic chemistry challenges
  • Experience in leading drug discovery projects from hit ID to development is a must
  • Experience understanding and writing patent applications
  • Excellent organization skills as an individual contributor AND in leading or co-leading multidisciplinary drug discovery project teams are desired
  • Ability to work independently and influence decision making within cross-functional teams
  • Organized, results-driven, detail-oriented, and able to multi-task
  • Highly motivated individual willing to go above and beyond to be successful and to be a key contributor in a highly innovative company
  • Strong verbal communication and writing skills are required
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